E 45th St, Grand Central, Medical Office Space For Rent 6,700 – 14,900 SF

E 45th St, Grand Central, Medical Office Space For Rent 6,700 – 14,900 SF

E 45th St, Grand Central, Medical Office Space For Rent 6,700 – 14,900 SF

• Built space with perimeter offices and open area
• The space can be divided to create a 6700 sf or 8200 sf division

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Property Overview

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Positioned in the heart of Manhattan’s Grand Central district, East 45th Street is an ENERGY STAR-certified office building offering 230,000 square feet across 18 stories. This modern property is perfectly suited for professional service firms, creative studios, and a wide variety of business operations.

Step into an elegant, attended lobby featuring high-end finishes and sleek stonework, setting the tone for a premium work environment. The building includes four passenger elevators, a dedicated freight elevator, and a convenient loading dock — all managed with responsive, hands-on attention from ownership.

A variety of flexible office layouts are currently available for lease, with ceiling heights reaching up to 12 feet and tenant-controlled HVAC systems.

Designed for both productivity and comfort, floor plans accommodate everything from private offices and open workstations to meeting rooms, kitchens, phone booths, and collaborative areas. New installations can be provided to meet tenant specifications.

Enjoy abundant natural light throughout the day and take in panoramic Midtown views from nearly every suite. The building’s strategic location offers excellent connectivity: just a short walk from Grand Central Terminal with access to multiple subway lines and Metro-North trains. For those commuting by car, adjacent parking garages provide added convenience.

Surrounded by iconic landmarks such as the United Nations Headquarters, the Chrysler Building, and Bryant Park, E 45th Street delivers the ideal balance of premium workspace and exceptional accessibility — the perfect destination for businesses seeking both prestige and practicality in Midtown Manhattan.

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Building Amenities

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• 24 Hour Access
• Bus Line
• Commuter Rail
• Metro/Subway
• Security System
• Energy Star Labeled
• Air Conditioning

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Transportation in Grand Central Station

In this region, Grand Central Terminal is a primary transportation hub. It serves Metro-North trains and the East Side 4, 5, and 6 local and express subway lines. Grand Central acts as a central core for transit in Midtown Manhattan, offering rail, subway, bus, taxi, and airport service all within steps of the Main Concourse. Grand Central Terminal main entrance is 89 E. 42nd Street (at Park Avenue), New York, NY 10017. It is accessible via the 4, 5, 6, 7, and S subway lines, the M101, M102, M103, M1, M2, M3, M4, Q32, and M42 buses and the Hudson, Harlem, and New Haven lines on Metro-North.

Grand Central–42nd Street

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